Medical Research Institute - Department of Advanced MedicineDivision of AGEs Research (Advanced Glycation End-products Research)

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TAGE病因説

Advanced glycation end-products (AGEs) generated with aging or in the presence of diabetes mellitus, particularly AGEs derived from the glucose/fructose metabolism intermediate glyceraldehyde (Glycer-AGEs; termed toxic AGEs (TAGE)), were recently shown to be closely involved in the onset and progression of diabetic vascular complications via the receptor for AGEs (RAGE). TAGE also contribute to various diseases, such as cardiovascular disease, nonalcoholic steatohepatitis, cancer, Alzheimer’s disease, and infertility. This suggests the necessity of minimizing the influence of the TAGE-RAGE axis in order to prevent the onset and progression of lifestyle-related diseases (LSRD) and establish therapeutic strategies. Changes in serum TAGE levels are closely associated with LSRD related to overeating, a lack of exercise, or excessive ingestion of sugars/dietary AGEs. We also showed that serum TAGE levels, but not those of hemoglobin A1c (HbA1c), glucose-derived AGEs, or N-(carboxymethyl)lysine, have potential as a biomarker for predicting the progression of atherosclerosis and future cardiovascular events. We have also demonstrated the usefulness of serum TAGE levels as a biomarker for the prevention and early diagnosis of LSRD and the evaluation of the efficacy of treatments. We aim to show whether dietary AGE/sugar intake restrictions reduce the generation and accumulation of TAGE, thereby preventing the onset and progression of LSRD.

Contact Information

TEL: 076-218-8456(直) +81-76-218-8456  / FAX: / Email: takeuchi@kanazawa-med.ac.jp

Faculty

Professor

  • TAKEUCHI Masayoshi 竹内顔写真

Senior Assistant Professor

  • TAKATA Takanobu

Assistant Professor

  • SAKASAI-SAKAI Akiko

External Research Funding

  • 2018-2020 JSPS KAKENHI Grant Number 18K11003 [Grant-in-Aid for Scientific Research (C)]: Correlation between onset of NASH and increment of reactive oxygen species induced by glycation in antioxidant protein. Akiko Sakasai-Sakai
  • 2018-2020 JSPS KAKENHI Grant Number 18K11139 [Grant-in-Aid for Scientific Research (C)]: Elucidation of myocardial cell damage caused by toxic advanced glycation end-products and its mechanism. Takanobu Takata
  • 2016-2019 JSPS KAKENHI Grant Number 16H01811 [Grant-in-Aid for Scientific Research (A)]: Clarification of the synthesis/accumulation of intracellular toxic advanced glycation end-products, in which currently consumed drinks/foods are involved, and mechanism of various cell disorders.Masayoshi Takeuchi
  • 2013-2017 MEXT〔Regional Innovation Strategy Support Program〕: Involvement of toxic AGEs (TAGE) as new targets in the onset and progression of lifestyle-related diseases and inhibition thereof.Masayoshi Takeuchi
  • 2013-2015 JSPS KAKENHI Grant Number 25282029〔Grant-in-Aid for Scientific Research (B)〕: Involvement of the dietary habits and the development and progression of nonalcoholic steatohepatisis.Masayoshi Takeuchi